Vincent R G, Pickren J W, Lane W W, Bross I, Takita H, Houten L, Gutierrez A C, Rzepka T
Cancer. 1977 Apr;39(4):1647-55. doi: 10.1002/1097-0142(197704)39:4<1647::aid-cncr2820390439>3.0.co;2-h.
We have reviewed the histopathology of lung cancer patients seen over the past 13 years at RPMI. Assessment of this data indicates that adenocarcinoma is becoming progressively more prevalent as related to the other forms of lung cancer. Factors which in part may account for this increased prevalence are: 1) changes in criteria for reading histopathology of lung cancer, particularly since 1967; 2) the increased incidence of lung cancer among the female population who have a propensity for adenocarcinoma; and 3) occupational and environmental factors. In 1974 adenocarcinoma for the first time became the most prevalent type of lung cancer at RPMI. Whatever the reason, if our data are truly representative of a national trend, adenocarcinoma will soon become the most prevalent type of lung cancer in the United States. This fact may result in an increasing death rate since the present 18-month survival rate for adenocarcinoma is substantially less than for squamous cell carcinoma, which has in the past been the prevalent form of the disease. As the smoking habits of women more closely approximate those of men, we expect that the incidence and mortality of lung cancer will prove to be quite similar in both sexes.
我们回顾了过去13年里在RPMI所诊治的肺癌患者的组织病理学情况。对这些数据的评估表明，腺癌与其他类型的肺癌相比，正变得越来越普遍。部分可能导致这种患病率增加的因素包括：1）肺癌组织病理学解读标准的变化，尤其是自1967年以来；2）易患腺癌的女性人群中肺癌发病率的增加；3）职业和环境因素。1974年，腺癌首次成为RPMI最常见的肺癌类型。无论原因是什么，如果我们的数据确实代表了全国趋势，那么腺癌很快将成为美国最常见的肺癌类型。这一事实可能导致死亡率上升，因为目前腺癌的18个月生存率远低于鳞状细胞癌，而鳞状细胞癌过去一直是该疾病的主要形式。随着女性吸烟习惯越来越接近男性，我们预计肺癌的发病率和死亡率在两性中将会相当相似。
