神经生长因子可预防单眼剥夺的弱视效应。
Nerve growth factor prevents the amblyopic effects of monocular deprivation.
作者信息
Domenici L, Berardi N, Carmignoto G, Vantini G, Maffei L
机构信息
Istituto di Neurofisiologia, Consiglio Nazionale delle Ricerche, Pisa, Italy.
出版信息
Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8811-5. doi: 10.1073/pnas.88.19.8811.
Abstract
Monocular deprivation early in life causes dramatic changes in the functional organization of mammalian visual cortex and severe reduction in visual acuity and contrast sensitivity of the deprived eye. We tested whether or not these changes could be from competition between the afferents from the two eyes for a target-derived neurotrophic factor. Rats monocularly deprived during early postnatal development were treated with repetitive intraventricular injections or topical administration of nerve growth factor. The effects of monocular deprivation were then assessed electrophysiologically. In untreated animals visual acuity and contrast sensitivity of the deprived eye were strongly reduced, whereas in nerve growth factor-treated animals these parameters were normal.
摘要
生命早期的单眼剥夺会导致哺乳动物视觉皮层功能组织发生显著变化，并使被剥夺眼的视敏度和对比敏感度严重降低。我们测试了这些变化是否可能源于两眼传入神经对靶源性神经营养因子的竞争。在出生后早期发育阶段进行单眼剥夺的大鼠，通过反复脑室内注射或局部应用神经生长因子进行治疗。然后通过电生理学方法评估单眼剥夺的影响。在未治疗的动物中，被剥夺眼的视敏度和对比敏感度大幅降低，而在接受神经生长因子治疗的动物中，这些参数是正常的。
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