Division of Biostatistics and Epidemiology, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts-Amherst, Amherst, Massachusetts, USA.
Fertil Steril. 2010 Mar 1;93(4):1104-11. doi: 10.1016/j.fertnstert.2008.12.018. Epub 2009 Feb 24.
To examine the association between stressful life events and semen parameters.
Cross-sectional analysis in a pregnancy cohort study.
Prenatal clinics in five U.S. cities.
PATIENT(S): Fertile men (n = 744) in the Study for Future Families, a cohort study of pregnant women and their partners.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Sperm concentration, percent motile, and percent normal morphology and classification above/below World Health Organization (WHO) cutoffs for semen quality.
RESULT(S): After adjusting for confounders, men reporting 2+ recent stressful life events had an increased risk of being classified below WHO thresholds for "normal" defined by concentration, motility, and morphology criteria compared with men reporting <2 stressful life events (odds ratio [OR] = 2.06; 95% confidence interval [CI], 1.18, 3.61; OR = 1.54; 95% CI, 1.04, 2.29; OR = 1.93; 95% CI, 1.02, 3.66 for concentration, motility and morphology, respectively). Men experiencing 2+ stressful life events had lower sperm concentration (log scale, beta = -0.25; 95% CI, -0.38, -0.11) and lower percent motile sperm (beta = -1.95; 95% CI, -3.98, 0.07), but percent normal morphology was less affected.
CONCLUSION(S): These results suggest that stressful life events may be associated with decreased semen quality in fertile men. The experience of psychosocial stress may be a modifiable factor in the development of idiopathic infertility.
探讨生活应激事件与精液参数的关系。
在一项妊娠队列研究中进行的横断面分析。
美国五个城市的产前诊所。
参加未来家庭研究的生育男性（n=744），这是一项对孕妇及其伴侣进行的队列研究。
无。
精子浓度、精子活动率和精子正常形态百分率，以及精液质量低于或高于世界卫生组织（WHO）标准的分类。
校正混杂因素后，与报告<2 项生活应激事件的男性相比，报告 2+项近期生活应激事件的男性，其精液浓度、活动率和形态符合“正常”定义的 WHO 标准的可能性较低（比值比[OR]分别为 2.06；95%置信区间[CI]为 1.18，3.61；OR=1.54；95%CI为 1.04，2.29；OR=1.93；95%CI为 1.02，3.66）。经历 2+项生活应激事件的男性，其精子浓度（对数标度，β=-0.25；95%CI，-0.38，-0.11）和精子活动率（β=-1.95；95%CI，-3.98，0.07）均较低，但精子正常形态百分率受影响较小。
这些结果提示，生活应激事件可能与生育男性精液质量下降有关。心理社会应激的体验可能是特发性不育症发生的一个可调节因素。
