Fujiwara Y, Takeda T, Kazahaya Y, Otsuki S, Sandyk R
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Int J Neurosci. 1988 Sep;42(1-2):77-84. doi: 10.3109/00207458808985762.
A behavioral study was made of the effect of carbamazepine (CBZ) on aggressive behavior evoked by high dose of clonidine in mice. This aggressive behavior has been reported to involve blockade of central adenosine receptors with which CBZ has been suggested to interact. After a single injection of clonidine (50 mg/kg i.p.), aggressive responses such as attacking and biting began within 5-10 min, were most marked at 20 min and usually ceased within 60 min. This behavior was attenuated by CBZ (45 mg/kg i.p.) but potentiated by caffeine (20 mg/kg i.p.). In addition, it was markedly inhibited by haloperidol (1.0 mg/kg i.p.), but unaffected by prazosin (1.5 mg/kg i.p.) and yohimbine (1.0 mg/kg i.p.). The inhibitory effect of CBZ on the aggressive behavior was dose-dependent at doses ranging from 15 to 60 mg/kg, while a high dose of CBZ alone induced sedation. The stimulatory effect of caffeine on the aggressive behavior was antagonized by pretreatment with CBZ (50 mg/kg i.p.). These results suggest that the receptor involved in clonidine-induced aggressive behavior was not mediated through the alpha-2 adrenoreceptor, but rather the adenosine receptor, and that the effect of carbamazepine on the adenosine receptor was agonistic in contrast with the effect of caffeine (an adenosine antagonist).
进行了一项行为学研究，以探讨卡马西平（CBZ）对高剂量可乐定诱发的小鼠攻击行为的影响。据报道，这种攻击行为涉及中枢腺苷受体的阻断，而CBZ被认为与该受体相互作用。单次注射可乐定（50mg/kg腹腔注射）后，攻击和撕咬等攻击反应在5-10分钟内开始，在20分钟时最为明显，通常在60分钟内停止。这种行为被CBZ（45mg/kg腹腔注射）减弱，但被咖啡因（20mg/kg腹腔注射）增强。此外，它被氟哌啶醇（1.0mg/kg腹腔注射）显著抑制，但不受哌唑嗪（1.5mg/kg腹腔注射）和育亨宾（1.0mg/kg腹腔注射）影响。CBZ对攻击行为的抑制作用在15至60mg/kg的剂量范围内呈剂量依赖性，而高剂量的CBZ单独使用会引起镇静作用。咖啡因对攻击行为的刺激作用被CBZ（50mg/kg腹腔注射）预处理所拮抗。这些结果表明，可乐定诱发攻击行为所涉及的受体不是通过α-2肾上腺素能受体介导的，而是通过腺苷受体介导的，并且卡马西平对腺苷受体的作用与咖啡因（一种腺苷拮抗剂）的作用相反，是激动性的。
