Carayan R, Mocaër E, Fabre-Thorpe M
Institut des Neurosciences, C.N.R.S. - U.P.M.C., Département de Neurophysiologie Comparée, Paris, France.
Psychopharmacology (Berl). 1991;104(3):328-36. doi: 10.1007/BF02246032.
Unlike other antidepressant drugs, tianeptine, when administered to cats at doses ranging from 1.2 to 5 mg/kg, produces an increase in arousal associated with longer sequences of immobile attentiveness. The present study analyses tianeptine-induced effects on visuomotor performance. Cats were trained to perform a pointing movement towards a randomly moving spot of light. Following tianeptine treatment (5 mg/kg), visuomotor performance was totally disrupted. When 2.5 mg/kg tianeptine was used, the accuracy of performance was unaffected, whereas the latency of movement onset was considerably and consistently increased. On a number of occasions the movement took also longer to perform. Following lower doses (0.6-1.2 mg/kg), performance was rarely impaired; in contrast, an improvement of visuo-motor scores was observed. This improvement was mostly characterized by an increased accuracy and could be associated with shorter latencies of movement onset or shorter movement times. Desipramine, another antidepressant drug having few sedative effects, induced a clear delay of movement onset when first administered. Further injections did not produce any changes in the visuo-motor performance. These results are discussed in relation with other effects of tianeptine, in particular its facilitatory effect on attentional processes.
与其他抗抑郁药物不同，当以1.2至5毫克/千克的剂量给猫服用时，噻奈普汀会引起觉醒增加，并伴有更长时间的静止注意力序列。本研究分析了噻奈普汀对视觉运动表现的影响。训练猫对一个随机移动的光点进行指向运动。在接受噻奈普汀治疗（5毫克/千克）后，视觉运动表现完全被打乱。当使用2.5毫克/千克的噻奈普汀时，表现的准确性未受影响，而运动开始的潜伏期则显著且持续增加。在许多情况下，完成运动所需的时间也更长。在较低剂量（0.6 - 1.2毫克/千克）下，表现很少受到损害；相反，观察到视觉运动评分有所提高。这种提高主要表现为准确性增加，可能与运动开始潜伏期缩短或运动时间缩短有关。地昔帕明是另一种几乎没有镇静作用的抗抑郁药物，首次给药时会明显延迟运动开始。进一步注射对视觉运动表现没有产生任何变化。结合噻奈普汀的其他作用，特别是其对注意力过程的促进作用，对这些结果进行了讨论。
