Defrance R, Marey C, Kamoun A
Institut de Recherches Internationales Servier, Neuilly-sur-Seine, France.
Clin Neuropharmacol. 1988;11 Suppl 2:S74-82.
Tianeptine is a new antidepressant effective against anxiety accompanying mood disturbances. Its clinical properties have been assessed by double-blind controlled studies (versus imipramine, amitriptyline, nomifensine, viloxazine) in depressed patients fulfilling the diagnostic criteria of the DSM III: single recurrent major depressive episodes without melancholia or psychotic features, and dysthymic disorders. The authors have concluded that tianeptine is effective in depressive disorders as shown both by depression rating scales and subjective impressions of treated patients. This improvement increases regularly with time. Seventy-eight percent of patients were considered to be "responders" at the end of the treatment with tianeptine. Antidepressant activity of tianeptine is equally present in depressive states appearing after withdrawal from alcohol. In depressed patients with anxiety, the results also reveal the efficacy of tianeptine on anxiety symptoms. Tianeptine, in addition, shows a marked action on somatic complaints. These results have been confirmed by open long-term trials, particularly in the elderly. Tianeptine can be placed in a middle position in the bipolar classification, between the sedative and stimulant antidepressants. Its antidepressant and anxiolytic properties and its action on somatic complaints make the drug particularly suitable for the treatment of the entire range of depressive symptomatology.
噻奈普汀是一种新型抗抑郁药，对伴有情绪障碍的焦虑有效。通过双盲对照研究（与丙咪嗪、阿米替林、诺米芬辛、维洛沙嗪对比），对符合DSM III诊断标准的抑郁症患者进行了评估：单次复发性重度抑郁发作，无 melancholia 或精神病性特征，以及心境恶劣障碍。作者得出结论，噻奈普汀在抑郁症中有效，这在抑郁评定量表和接受治疗患者的主观印象中均有体现。这种改善随时间有规律地增加。78%的患者在接受噻奈普汀治疗结束时被认为是“有反应者”。噻奈普汀的抗抑郁活性在戒酒后出现的抑郁状态中同样存在。在伴有焦虑的抑郁症患者中，结果也显示了噻奈普汀对焦虑症状的疗效。此外，噻奈普汀对躯体不适有显著作用。这些结果已通过开放性长期试验得到证实，尤其是在老年人中。噻奈普汀在双相分类中可处于中间位置，介于镇静性和兴奋性抗抑郁药之间。其抗抑郁和抗焦虑特性以及对躯体不适的作用，使该药物特别适合治疗整个范围的抑郁症状。
