运动和PGC1α在炎症与慢性疾病中的作用。
The role of exercise and PGC1alpha in inflammation and chronic disease.
作者信息
Handschin Christoph, Spiegelman Bruce M
机构信息
Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, CH-8057 Zurich, Switzerland.
出版信息
Nature. 2008 Jul 24;454(7203):463-9. doi: 10.1038/nature07206.
Abstract
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.
摘要
缺乏体育活动与许多慢性疾病有关。但将肌肉活动与健康联系起来的机制尚不清楚。转录共激活因子PGC1α最近已被证明可调节肌肉功能的几个与运动相关的方面。我们认为这种蛋白质控制肌肉可塑性，抑制广泛的炎症反应，并介导运动的有益效果。
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