阿尔布西定：一种来自白色链霉菌绿亚种NRRL B - 24108的新型漂白除草剂。

Albucidin: a novel bleaching herbicide from Streptomyces albus subsp. chlorinus NRRL B-24108.

作者信息

Hahn Donald R, Graupner Paul R, Chapin Eleanor, Gray John, Heim D, Gilbert Jeffrey R, Gerwick B Clifford

机构信息

Discovery Research, Dow AgroSciences, LLC, Indianapolis, IN 48268-1054, USA.

出版信息

J Antibiot (Tokyo). 2009 Apr;62(4):191-4. doi: 10.1038/ja.2009.11. Epub 2009 Feb 27.

DOI:10.1038/ja.2009.11

PMID:19247393

Abstract

A novel nucleoside phytotoxin, albucidin (1), was isolated from the culture broth of Streptomyces albus subsp. chlorinus NRRL B-24108 using bioassay directed fractionation. The structure of the new natural product, albucidin, was determined by NMR and MS; however, the compound has been reported earlier in the literature following synthetic modification of oxetanocin. This is the first report of herbicidal activity for compounds of this structural type. Albucidin shows high levels of broad spectrum activity following post-emergence applications as well as moderate levels of pre-emergence activity. Accordingly, albucidin could be an important new lead for herbicide discovery.

摘要

一种新型核苷类植物毒素——阿布尔西定（1），通过生物活性导向分级分离法从白色链霉菌亚种绿链霉菌NRRL B - 24108的培养液中分离得到。新型天然产物阿布尔西定的结构通过核磁共振（NMR）和质谱（MS）确定；然而，该化合物在文献中早有报道，是对氧杂环丁菌素进行合成修饰后得到的。这是关于这种结构类型化合物除草活性的首次报道。阿布尔西定在苗后施用时表现出高广谱活性，在苗前施用时也表现出中等活性。因此，阿布尔西定可能是除草剂发现领域的一个重要新先导化合物。