阿尔比多吡喃酮，一种源自海洋链霉菌NTK 227的含新型α-吡喃酮的代谢产物。

Albidopyrone, a new alpha-pyrone-containing metabolite from marine-derived Streptomyces sp. NTK 227.

作者信息

Hohmann Claudia, Schneider Kathrin, Bruntner Christina, Brown Roselyn, Jones Amanda L, Goodfellow Michael, Krämer Marco, Imhoff Johannes F, Nicholson Graeme, Fiedler Hans-Peter, Süssmuth Roderich D

机构信息

Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.

出版信息

J Antibiot (Tokyo). 2009 Feb;62(2):75-9. doi: 10.1038/ja.2008.15. Epub 2009 Jan 9.

DOI:10.1038/ja.2008.15

PMID:19132055

Abstract

Albidopyrone, a new alpha-pyrone-containing secondary metabolite, was produced by Streptomyces sp. NTK 227, a strain isolated from Atlantic Ocean sediment and found to be a member of the Streptomyces albidoflavus 16S rRNA gene clade. The structure of the compound was determined by MS and NMR spectroscopy, and found to have a moderate inhibitory activity against protein-tyrosin phosphatase B.

摘要

阿尔比多吡喃酮是一种新的含α-吡喃酮的次生代谢产物，由链霉菌属NTK 227产生，该菌株从大西洋沉积物中分离得到，属于白黄链霉菌16S rRNA基因分支。该化合物的结构通过质谱和核磁共振光谱确定，发现其对蛋白酪氨酸磷酸酶B具有中等抑制活性。