Pöller F, Sauerwein W, Rassow J
Department of Medical Radiation Physics, University of Essen, F.R.G.
Radiother Oncol. 1991 Jul;21(3):179-82. doi: 10.1016/0167-8140(91)90035-f.
Incorporation of 10B in human tumours treated with fast neutrons would increase the local dose in the tumour. In tissue the neutrons are thermalized mainly causing the neutron capture reaction 10B (n,a) 7Li. The dose enhancement can be calculated using the thermal neutron fluence measured by activation of gold foils in a phantom. At a phantom depth of 5 cm a dose enhancement of (0.056 +/- 0.0028)% for each microgram of 10B per gram of tissue was determined in the tumour. A therapeutic gain by this dose enhancement in fast neutron therapy should be examined for a solid tumour in a mouse. The feasibility for neutron capture therapy of tumours in mice depends on the distribution of the tumour dose and on the effective shielding of the bodies of the mice. Therefore, a special holding device for simultaneous irradiation of four tumours was developed. The dose distribution in the tumours and in the surrounding bodies of mice was measured with TLD-300 in a special mouse phantom.
在接受快中子治疗的人体肿瘤中掺入硼-10会增加肿瘤内的局部剂量。在组织中，中子被热化，主要引发硼-10的中子俘获反应10B（n，α）7Li。剂量增强可通过在模体中用金箔活化测量的热中子注量来计算。在模体深度为5厘米处，在肿瘤中确定每克组织中每微克硼-10的剂量增强为（0.056±0.0028）%。应针对小鼠体内的实体瘤研究这种剂量增强在快中子治疗中的治疗增益。小鼠肿瘤的中子俘获治疗的可行性取决于肿瘤剂量的分布以及小鼠身体的有效屏蔽。因此，开发了一种用于同时照射四个肿瘤的特殊固定装置。在特殊的小鼠模体中用TLD-300测量了肿瘤及小鼠周围身体中的剂量分布。
