Budach V, Olthoff-Münter K, Frank H U, Tessler H
Department of Radiooncology, University of Essen, F.R.G.
Int J Rad Appl Instrum A. 1988;39(4):297-301. doi: 10.1016/0883-2889(88)90019-6.
Fast neutron irradiation of human xenografts in the flanks of nude mice is mainly a technical problem. The feasibility is dependent on the distribution of the tumor absorbed dose DT and on an effective shielding of the bodies of the animals. Therefore a special holding device for simultaneous irradiation of two tumour-bearing animals was developed. Meticulous dosimetric investigations using TLD-300 detectors in a mouse phantom showed that a relatively homogeneous dose distribution could be achieved in the xenografts and that effective shielding of the mice from direct irradiation would be achieved; the dose for the bodies of the animals being less than 10% of the dose to the tumour. Thus survival and a sufficient follow-up period of the irradiated animals could be guaranteed for all preclinical dose ranges used.
对裸鼠侧腹的人异种移植瘤进行快中子辐照主要是一个技术问题。其可行性取决于肿瘤吸收剂量DT的分布以及对动物身体的有效屏蔽。因此，开发了一种用于同时辐照两只荷瘤动物的特殊固定装置。在小鼠模型中使用TLD - 300探测器进行的细致剂量学研究表明，在异种移植瘤中可以实现相对均匀的剂量分布，并且可以有效屏蔽小鼠免受直接辐照；动物身体所受剂量小于肿瘤所受剂量的10%。因此，对于所有使用的临床前剂量范围，都可以保证辐照动物的存活和足够的随访期。
