Department of Pathology, Women and Infants Hospital101 Dudley St. Providence, Rhode Island 02905, USA.
Fertil Steril. 2010 Feb;93(2):397-404. doi: 10.1016/j.fertnstert.2008.12.144. Epub 2009 Feb 26.
To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies.
Retrospective case-control study.
Academic medical center.
PATIENT(S): The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry.
RESULT(S): There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group.
CONCLUSION(S): There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon.
比较接受供卵体外受精（IVF）与非供卵 IVF 妊娠的胎盘病理学和母胎界面免疫反应。
回顾性病例对照研究。
学术医疗中心。
研究人群包括 20 例接受供卵和 33 例非供卵 IVF 妊娠且孕周>24 周的患者。
无。
围产期并发症（妊娠期高血压、胎盘早剥、早产、剖宫产）、提示免疫反应和滋养层损伤的微观特征，以及免疫组织化学法对炎症细胞的特征分析。
供卵妊娠中妊娠期高血压和早产的发生率增加。供卵胎盘的基底蜕膜中可见密集的纤维蛋白沉积，慢性蜕膜炎严重，其中 T 辅助细胞和自然杀伤细胞数量明显增加。早产供卵组的滋养层损伤也增加。
供卵和非供卵 IVF 妊娠的胎盘在组织学和免疫组织化学方面存在显著差异。供卵妊娠母胎界面的免疫活性和纤维蛋白沉积增加，可能代表宿主对移植物的排斥反应样现象。
