Bhattacharjee Rakesh, Kheirandish-Gozal Leila, Pillar Giora, Gozal David
Kosair Children's Hospital Research Institute, Louisville, KY 40202, USA.
Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):416-33. doi: 10.1016/j.pcad.2008.03.002.
Obstructive Sleep Apnea Syndrome (OSAS) is a common condition in children, and is characterized by intermittent partial or complete occlusion of the upper airway during sleep, leading to profound disturbances in homeostatic gas exchange, frequent arousals and disturbed sleep architecture. Pediatric OSAS is associated with a multitude of end-organ morbidities, most of which have been uncovered in the last decade. Of particular interest are the cardiovascular complications that may develop in children with OSAS, since they are posited to have not only an immediately significant impact on cardiovascular health during childhood, but may also affect cardiovascular outcomes later during adult life. In this review, we will present the specific cardiovascular complications that have thus far been described in children with OSAS, with reference to pertinent mechanisms, and potential implications.
阻塞性睡眠呼吸暂停综合征（OSAS）在儿童中很常见，其特征是睡眠期间上呼吸道间歇性部分或完全阻塞，导致体内气体交换的严重紊乱、频繁觉醒和睡眠结构紊乱。小儿OSAS与多种终末器官疾病相关，其中大多数是在过去十年中发现的。特别值得关注的是OSAS患儿可能出现的心血管并发症，因为这些并发症不仅被认为会在儿童期对心血管健康产生直接重大影响，还可能影响成年后的心血管结局。在这篇综述中，我们将介绍迄今为止在OSAS患儿中描述的特定心血管并发症，参考相关机制及潜在影响。
