Bashutski Jill D, Wang Hom-Lay
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA.
J Endod. 2009 Mar;35(3):321-8. doi: 10.1016/j.joen.2008.11.023.
Guided tissue regeneration (GTR) is effective in halting tissue and bone destruction and promoting new tissue and bone formation. Although the goal of complete and predictable regeneration still remains elusive, many techniques and materials have been developed that show good clinical and histologic outcomes. The most commonly used materials in GTR include bone replacement grafts from numerous sources, nonresorbable and bioabsorbable membranes, and recently growth hormones/cytokines and other host modulating factors. This article reviews the biologic rationale behind current techniques used for tissue/bone regeneration, reviews the most common materials and techniques, and attempts to explain the factors that influence the outcomes of these therapies.
引导组织再生（GTR）在阻止组织和骨破坏以及促进新组织和骨形成方面是有效的。尽管完全可预测的再生目标仍然难以实现，但已经开发出了许多显示出良好临床和组织学结果的技术和材料。GTR中最常用的材料包括来自多种来源的骨替代移植物、不可吸收和可生物吸收的膜，以及最近的生长激素/细胞因子和其他宿主调节因子。本文回顾了用于组织/骨再生的当前技术背后的生物学原理，回顾了最常见的材料和技术，并试图解释影响这些治疗结果的因素。
