Coppes Rob P, van der Goot Annemieke, Lombaert Isabelle M A
Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Semin Radiat Oncol. 2009 Apr;19(2):112-21. doi: 10.1016/j.semradonc.2008.11.005.
Normal tissue damage after radiotherapy is still a major problem in cancer treatment. Stem cell therapy may provide a means to reduce radiation-induced side effects and improve the quality of life of patients. This review discusses the current status in stem cell research with respect to their potential to reduce radiation toxicity. A number of different types of stem cells are being investigated for their potential to treat a variety of disorders. Their current status, localization, characterization, isolation, and potential in stem cell-based therapies are addressed. Although clinical adult stem cell research is still at an early stage, preclinical experiments show the potential these therapies may have. Based on the major advances made in this field, stem cell-based therapy has great potential to allow prevention or treatment of normal tissue damage after radiotherapy.
放疗后正常组织损伤仍是癌症治疗中的一个主要问题。干细胞疗法可能提供一种减少辐射诱导副作用并改善患者生活质量的方法。本综述讨论了干细胞研究在降低辐射毒性潜力方面的现状。目前正在研究多种不同类型的干细胞治疗各种疾病的潜力。文中探讨了它们在基于干细胞的疗法中的现状、定位、特征、分离方法及潜力。虽然临床成人干细胞研究仍处于早期阶段，但临床前实验显示了这些疗法可能具有的潜力。基于该领域取得的重大进展，基于干细胞的疗法在预防或治疗放疗后正常组织损伤方面具有巨大潜力。
