Ryzhii Elena, Wei Daming
Division of Information Systems, Biomedical Information Technology Laboratory, University of Aizu, Aizu-Wakamatsu, Japan.
J Electrocardiol. 2009 Jul-Aug;42(4):319-27. doi: 10.1016/j.jelectrocard.2008.12.015. Epub 2009 Feb 28.
Recently, the so-called atypical Brugada syndrome (BS) has been reported in few cases in literature. The typical BS is characterized by ST-segment elevation in the right precordial leads, whereas atypical forms of the disease are distinguished by electrocardiogram abnormalities of the J wave, and ST-segment elevation appeared in the inferior and lateral leads. In this work, we report a simulation of atypical BS based on a 3-dimensional whole-heart model. By setting the action potentials of Brugada model cells in different epicardial regions, we calculated 12-lead electrocardiogram and body surface potentials that are in good agreement with clinical data. Applying additional electrical stimuli, we obtained the induction of ventricular fibrillation in both typical and atypical BS forms. The calculated results confirm possibility of similar electrophysiological basis in both cases and suggest that BS can also be observed in inferior and lateral precordial leads.
最近，文献中报道了少数几例所谓的非典型 Brugada 综合征（BS）病例。典型的 BS 特征为右胸前导联 ST 段抬高，而该疾病的非典型形式则以 J 波心电图异常以及下壁和侧壁导联出现 ST 段抬高为特征。在这项研究中，我们报告了基于三维全心模型对非典型 BS 的模拟。通过设置不同心外膜区域的 Brugada 模型细胞动作电位，我们计算出的 12 导联心电图和体表电位与临床数据高度吻合。施加额外的电刺激后，我们在典型和非典型 BS 形式中均诱发了心室颤动。计算结果证实了两种情况下存在相似电生理基础的可能性，并表明在下壁和侧壁胸前导联也可观察到 BS。
