在寻找新型放射增敏剂的道路上。
On the path to seeking novel radiosensitizers.
作者信息
Katz David, Ito Emma, Liu Fei-Fei
机构信息
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
出版信息
Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):988-96. doi: 10.1016/j.ijrobp.2008.12.002.
Radiation therapy is a highly effective cancer treatment modality, and extensive investigations have been undertaken over the years to augment its efficacy in the clinic. This review summarizes the current understanding of the biologic bases underpinning many of the clinically used radiosensitizers. In addition, this review illustrates how the advent of innovative, high-throughput technologies with integration of different disciplines could be harnessed for an expeditious discovery process for novel radiosensitizers, providing an exciting future for such pursuits in radiation biology and oncology.
放射治疗是一种高效的癌症治疗方式，多年来人们进行了广泛的研究以提高其临床疗效。本综述总结了目前对许多临床使用的放射增敏剂的生物学基础的理解。此外，本综述还阐述了如何利用创新的高通量技术以及不同学科的整合来加速新型放射增敏剂的发现过程，为放射生物学和肿瘤学领域的此类研究提供了令人兴奋的前景。
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