Kawano Atsuko, Emori Yoko, Miyagawa Sachiyo
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1-D, Tennodai Tsukuba, Ibaraki, Japan.
Biol Res Nurs. 2009 Apr;10(4):350-5. doi: 10.1177/1099800409331892. Epub 2009 Feb 26.
We examined the association between biochemical parameters of stress in puerperae and immune substances in breast milk.
The participants were 22 mothers 2 weeks after delivery, with normal pregnancy/delivery and a normal puerperal course. We measured the levels of secretory immunoglobulin A (SIgA) and cortisol in saliva and the level of SIgA and the leukocyte count in breast milk and investigated their association.
There was a positive correlation between the salivary and breast milk levels of SIgA (r = .536, p < .05). However, there were no correlations among the salivary level of cortisol and the level of SIgA and leukocyte count in breast milk.
The only association found in our study was between the salivary and breast milk SIgA. The lack of association among SIgA and cortisol may be related to a variety of factors such as production site, diurnal rhythms, and the interval between stress stimulation in mothers and the response of the biomarker.
我们研究了产后妇女应激的生化参数与母乳中免疫物质之间的关联。
参与者为22名产后2周的母亲，她们妊娠/分娩正常且产褥期过程正常。我们测量了唾液中分泌型免疫球蛋白A（SIgA）和皮质醇的水平以及母乳中SIgA的水平和白细胞计数，并研究了它们之间的关联。
唾液和母乳中SIgA的水平呈正相关（r = 0.536，p < 0.05）。然而，唾液皮质醇水平与母乳中SIgA水平和白细胞计数之间没有相关性。
我们的研究中发现的唯一关联是唾液和母乳中的SIgA之间的关联。SIgA与皮质醇之间缺乏关联可能与多种因素有关，如产生部位、昼夜节律以及母亲应激刺激与生物标志物反应之间的间隔。
