Talavera David, Laskowski Roman A, Thornton Janet M
EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Bioinformatics. 2009 May 1;25(9):1192-4. doi: 10.1093/bioinformatics/btp116. Epub 2009 Feb 27.
Annotation tools help scientists to traverse the gap between characterized and uncharacterized proteins. Tools for the prediction of protein function include those which predict the function of entire proteins or complexes, those annotating functional domains and those which predict specific residues within the domain. We have developed WSsas, a web service focused on the annotation of essential functional residues. WSsas uses similarity searches and pairwise alignments to transfer functional information about binding, catalytic and protein-protein interaction residues from solved structures to query sequences. In addition, WSsas can supply information about the relevant functional atoms. The web service definition (WSDL) file and a Perl client are freely available at http://www.ebi.ac.uk/thornton-srv/databases/WSsas/.
注释工具帮助科学家跨越已表征蛋白质和未表征蛋白质之间的差距。蛋白质功能预测工具包括预测整个蛋白质或复合物功能的工具、注释功能域的工具以及预测功能域内特定残基的工具。我们开发了WSsas，这是一个专注于注释关键功能残基的网络服务。WSsas使用相似性搜索和成对比对，将关于结合、催化和蛋白质-蛋白质相互作用残基的功能信息从已解析结构转移到查询序列。此外，WSsas可以提供有关相关功能原子的信息。网络服务定义（WSDL）文件和一个Perl客户端可从http://www.ebi.ac.uk/thornton-srv/databases/WSsas/免费获取。
