复发缓解型多发性硬化症患者中，多重硬化相关逆转录病毒因子（MSRV）刺激的细胞因子产生
Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.
作者信息
Saresella M, Rolland A, Marventano I, Cavarretta R, Caputo D, Marche P, Perron H, Clerici M
机构信息
Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation IRCCS, Via Capecelatro, 66, Milano 20148, Italy.
出版信息
Mult Scler. 2009 Apr;15(4):443-7. doi: 10.1177/1352458508100840. Epub 2009 Feb 27.
BACKGROUND
Human endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients.
OBJECTIVE AND METHODS
We analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear cells of 30 relapsing-remitting MS patients with either acute (AMS) (n = 13) or stable (SMS) (n = 17) disease. Results suggest that MSRV ENV-SU induces the production of inflammatory cytokines, including tumor necrosis factor-alpha (P < 0.05) and interferon-gamma (P < 0.004) in AMS patients and of interleukin-10 (P < 0.05), an inflammation-dampening cytokine, in SMS individuals.
CONCLUSIONS
These data strengthen the hypothesis indicating that MSRV could be involved in the pathogenesis of MS.
背景
人类内源性逆转录病毒被认为在多发性硬化症（MS）中发挥致病作用；其中一种逆转录病毒，即与MS相关的逆转录病毒因子（MSRV），已在MS患者中多次分离出来。
目的和方法
我们分析了30例复发缓解型MS患者外周血单核细胞在MSRV包膜蛋白（MSRV ENV-SU）刺激下的细胞因子谱，这些患者分别处于急性（AMS）（n = 13）或稳定期（SMS）（n = 17）疾病状态。结果表明，MSRV ENV-SU在AMS患者中诱导炎性细胞因子的产生，包括肿瘤坏死因子-α（P < 0.05）和干扰素-γ（P < 0.004），而在SMS个体中诱导白细胞介素-10（P < 0.05）的产生，白细胞介素-10是一种减轻炎症的细胞因子。
结论
这些数据强化了MSRV可能参与MS发病机制的假说。
Zotero 插件