Tsutsumi Akito, Kobayashi Tetsuo, Ito Satoshi, Goto Daisuke, Matsumoto Isao, Yoshie Hiromasa, Sumida Takayuki
Division of Clinical Immunology, Advanced Biomedical Applications, Graduate School of Comprehensive Human Science, University of Tsukuba.
Nihon Rinsho Meneki Gakkai Kaishi. 2009 Feb;32(1):48-52. doi: 10.2177/jsci.32.48.
Mannose binding lectin (MBL) is a key molecule in first line defense against various microorganisms. Polymorphism of the MBL gene greatly affects serum MBL concentration, and is known to be associated with occurrence of infectious diseases. We aimed to determine whether there is a relationship between occurrence or severity of chronic periodontitis (CP) and polymorphism of the MBL gene.
Ninety-eight CP patients and 63 healthy subjects with no periodontitis were typed for the codon 54 polymorphism of the MBL gene by PCR-restriction fragment length polymorphism method.
Genotype frequencies of the codon 54 polymorphism were similar between patients and control subjects. When patients were categorized to mild, moderate and severe periodontitis groups, possession of the low serum MBL concentration allele was a risk factor for having severe CP, as assessed by logistic regression analysis.
Patients with MBL genotypes that cause lower serum MBL concentration may be at risk of having severe periodontitis. MBL gene typing may become useful to predict the prognosis of CP.
甘露糖结合凝集素（MBL）是抵御各种微生物的一线防御中的关键分子。MBL基因多态性极大地影响血清MBL浓度，且已知与传染病的发生相关。我们旨在确定慢性牙周炎（CP）的发生或严重程度与MBL基因多态性之间是否存在关联。
采用聚合酶链反应-限制性片段长度多态性方法，对98例CP患者和63例无牙周炎的健康受试者进行MBL基因第54密码子多态性分型。
患者和对照受试者之间第54密码子多态性的基因型频率相似。当将患者分为轻度、中度和重度牙周炎组时，通过逻辑回归分析评估，拥有低血清MBL浓度等位基因是患重度CP的危险因素。
具有导致血清MBL浓度降低的MBL基因型的患者可能有患重度牙周炎的风险。MBL基因分型可能有助于预测CP的预后。
