Darmawan Anton Budhi, Soesatyo Marsetyawan H N E, Restuti Ratna Dwi, Surono Agus
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Jenderal Soedirman-Margono Soekarjo Hospital, Purwokerto, Indonesia.
Department of Cell Biology and Histology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Int J Otolaryngol. 2018 May 22;2018:6178159. doi: 10.1155/2018/6178159. eCollection 2018.
Chronic suppurative otitis media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment especially in developing countries. The role of Mannose-Binding Lectin (MBL), a component of innate immunity, in CSOM has not been studied. The aim of the study was to examine whether MBL deficiency was more frequently present in cases group of tubotympanic CSOM patients rather than healthy subjects.
This was an analytic observational study. Subjects were enrolled in the Otorhinolaryngology Clinic at Margono Soekarjo Hospital, Purwokerto, Indonesia. An independent -test was used to compare the mean of MBL serum concentration between tubotympanic CSOM subjects and control.
From 36 tubotympanic CSOM patients, there were 8 (22.22%) patients with MBL deficiency (MBL level < 100 ng/ml), while no deficiency was found in the control group. The mean of MBL level in cases group was 354.88 ng/ml, with the lowest level being 0.001 ng/ml and the highest level 690.24 ng/ml, while in the control group MBL level mean was 376.27 with the lowest level being 188.71 and the highest level 794.54 ng/ml.
There was no significant difference of MBL serum level between tubotympanic CSOM and control group. However, the presence of subjects with MBL deficiency in the tubotympanic CSOM group might be considered as playing a role in the tubotympanic CSOM.
慢性化脓性中耳炎（CSOM）是全球常见的公共卫生问题，也是听力障碍的主要原因，尤其是在发展中国家。甘露糖结合凝集素（MBL）作为天然免疫的一个组成部分，在CSOM中的作用尚未得到研究。本研究的目的是检验在鼓室乳突型CSOM患者病例组中，MBL缺乏是否比健康受试者更常见。
这是一项分析性观察研究。研究对象来自印度尼西亚Purwokerto的Margono Soekarjo医院耳鼻喉科诊所。采用独立样本t检验比较鼓室乳突型CSOM受试者与对照组之间MBL血清浓度的均值。
在36例鼓室乳突型CSOM患者中，有8例（22.22%）患者存在MBL缺乏（MBL水平<100 ng/ml），而对照组未发现缺乏情况。病例组MBL水平均值为354.88 ng/ml，最低水平为0.001 ng/ml，最高水平为690.24 ng/ml，而对照组MBL水平均值为376.27，最低水平为188.71，最高水平为794.54 ng/ml。
鼓室乳突型CSOM与对照组之间MBL血清水平无显著差异。然而，鼓室乳突型CSOM组中存在MBL缺乏的受试者可能被认为在鼓室乳突型CSOM中发挥了作用。
