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[反应性关节炎和类风湿关节炎中耶尔森菌感染指标的评估方法]

[Approach to evaluation of the indicators of Yersinia infections in reactive and rheumatoid arthritis].

作者信息

Sidel'nikova S M, Agababova E R, Iushchenko G V, Aseeva E M, Elkina Iu B, Riazantseva T A, Borovik V Z

出版信息

Revmatologiia (Mosk). 1991 Apr-Jun(2):19-26.

PMID:1925260
Abstract

A total of 140 patients with reactive arthritis due to Yersinia infection were under observation for 2-10 years. A group of 104 patients with erosive rheumatoid arthritis served as control for analysis of the results of bacteriological and serological studies. The bacteriological analysis of the feces, urine, smears of the feces and blood were made repeatedly. As established the articular syndrome in reactive arthrosis has its specific features depending on the nature of the pathological process: primary, recurrent and chronic. Patients with primary reactive arthritis exhibited recovery without residual phenomena and relapses in 35.8% of the cases; in 86% the disease relapsed; in 36% it was chronic, persisting for a number of years as a non-erosive seronegative arthritis; in 25.3% arthralgia persisted; in 6.2% the clinical picture of secondary osteoarthrosis developed; in 17.3% the disease changed into spondyloarthritis and in 1.2% of the cases it changed into RA. Since in reactive arthritis Yersinia infection was confirmed in 48.5% of the cases and in RA in 14-21%, laboratory diagnosis cannot serve as an absolute criterion for reactive arthritis. It is necessary to take into consideration the anamnesis and the peculiarities of the clinical picture and the course of the articular syndrome.

摘要

共有140例因耶尔森菌感染导致反应性关节炎的患者接受了2至10年的观察。104例侵蚀性类风湿性关节炎患者作为对照组,用于分析细菌学和血清学研究结果。对粪便、尿液、粪便涂片和血液进行了多次细菌学分析。已确定反应性关节炎的关节综合征根据病理过程的性质具有其特定特征:原发性、复发性和慢性。原发性反应性关节炎患者中,35.8%的病例痊愈且无残留现象和复发;86%的病例疾病复发;36%为慢性,作为非侵蚀性血清阴性关节炎持续数年;25.3%的患者关节痛持续;6.2%的病例出现继发性骨关节炎的临床表现;17.3%的疾病转变为脊柱关节炎,1.2%的病例转变为类风湿性关节炎。由于在反应性关节炎中48.5%的病例确诊有耶尔森菌感染,而在类风湿性关节炎中为14%至21%,因此实验室诊断不能作为反应性关节炎的绝对标准。有必要考虑病史、临床表现的特点以及关节综合征的病程。

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