Moawad H M M, Jain H
Department of Materials Science and Engineering, Lehigh University, Bethlehem, PA 18015, USA.
J Mater Sci Mater Med. 2009 Jul;20(7):1409-18. doi: 10.1007/s10856-009-3711-7. Epub 2009 Feb 28.
We have extended the usefulness of bioactive glass-ceramics for the repair and reconstruction of hard tissues by introducing F ions that are known to be beneficial, especially in dentistry. Nano-macro multimodal porosity in soda-lime phosphofluorosilicate bulk samples was introduced by the recently developed melt-quench-heat-etch method. The choice of starting glass composition is based on 48SiO2-2.7P2O5-xCaF2-yCaO-zNa2O where x = 0, 1, 4, 8, 10, 12, and (y + z) = 49.3-x (mol%). The effect of thermal and chemical treatment on the microstructure of samples is characterized by SEM, XRD and EDX. We find the formation of many crystalline phases, but mainly sodium calcium silicate, calcium phosphate, fluorapatite and calcium silicate. The bioactivity of soda-lime phosphofluorosilicate glass-ceramics is assessed by monitoring the formation of hydroxyl apatite (HA) layer: fluorapatite phase accelerates the rate of HA layer formation; the initial composition and multi-modal porosity are other key parameters that impact the formation of HA. The present porous glass-ceramics should be superior candidates for use in dental bone regeneration.
通过引入已知有益的氟离子，特别是在牙科领域，我们扩展了生物活性玻璃陶瓷在硬组织修复和重建方面的用途。采用最近开发的熔体淬火 - 热蚀刻方法，在钠钙磷氟硅酸盐块状样品中引入了纳米 - 宏观多模态孔隙率。起始玻璃组成的选择基于48SiO2 - 2.7P2O5 - xCaF2 - yCaO - zNa2O，其中x = 0、1、4、8、10、12，且(y + z) = 49.3 - x（摩尔%）。通过扫描电子显微镜（SEM）、X射线衍射仪（XRD）和能谱仪（EDX）对样品微观结构的热和化学处理效果进行表征。我们发现形成了许多晶相，但主要是硅酸钠钙、磷酸钙、氟磷灰石和硅酸钙。通过监测羟基磷灰石（HA）层的形成来评估钠钙磷氟硅酸盐玻璃陶瓷的生物活性：氟磷灰石相加速了HA层的形成速率；初始组成和多模态孔隙率是影响HA形成的其他关键参数。目前的多孔玻璃陶瓷应是用于牙骨再生的优质候选材料。
