Thompson I D, Hench L L
Imperial College of Science, Technology and Medicine, London.
Proc Inst Mech Eng H. 1998;212(2):127-36. doi: 10.1243/0954411981533908.
The application of bioactive glass and glass-ceramics has been widely documented over the past twenty years but the high modulus and low fracture toughness has made them less applicable for clinical, load bearing, applications. The development of non-resorbable polyethylene and polysulphone matrices for these materials has improved the mechanical properties. However, the primary concern of whether the bioactivity of the composites is reduced is still unresolved. The more recent development of resorbable carrier systems, dextran and collagen, for bioactive glasses does not introduce such problems, hence making this form of composite suitable for novel soft tissue applications. The development of a simple quality index has enabled some of the materials described within this paper to be ranked by their ability to replace bone, thus enabling possible new research directions to be emphasized.
在过去二十年中，生物活性玻璃和玻璃陶瓷的应用已有大量文献记载，但高模量和低断裂韧性使其不太适用于临床承重应用。为这些材料开发的不可吸收聚乙烯和聚砜基体改善了机械性能。然而，复合材料的生物活性是否降低这一主要问题仍未得到解决。用于生物活性玻璃的可吸收载体系统（葡聚糖和胶原蛋白）的最新发展并未引入此类问题，因此使这种形式的复合材料适用于新型软组织应用。一种简单质量指标的开发使得本文所述的一些材料能够根据其替代骨的能力进行排名，从而能够强调可能的新研究方向。
