水中的有机合成：合成2-(环己基氨基)-3-芳基-茚并[1,2-b]呋喃-4-酮的绿色方法
Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones.
作者信息
Heravi Majid M, Baghernejad Bita, Oskooie Hossein A
机构信息
Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran.
出版信息
Mol Divers. 2009 Aug;13(3):385-7. doi: 10.1007/s11030-009-9122-3. Epub 2009 Feb 28.
PMID:19252994
Abstract
Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.
摘要
醛、1,3-茚二酮和环己基异氰化物在水中顺利进行偶联环化反应，以良好的产率生成相应的2-(环己基氨基)-3-芳基-茚并[1,2-b]呋喃-4-酮。使用水作为溶剂，以避免在该合成中使用其他剧毒且对环境不利的溶剂。
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