Chedraui Peter, San Miguel Glenda, Avila Carlos
Collaborative Group for Research of the Climacteric in Latin America (REDLINC, Ecuador Group 1), Guayaquil, Ecuador.
Gynecol Endocrinol. 2009 Feb;25(2):130-5. doi: 10.1080/09513590802617770.
To assess the female quality of life (QoL) during the menopausal transition and determine factors (personal and partner) related to its impairment. The frequency of menopausal symptoms was also assessed.
In this cross-sectional study, healthy women aged 40-59 years were asked to fill out the Menopause Rating Scale (MRS) and a questionnaire assessing personal and partner demographic data.
During the study period, a total of 409 women were surveyed. Mean age was 47 +/- 5.3 years (median 46). Mean educational level was 13.2 +/- 4.1 years (median 14), with 28.1% having 12 or less years of schooling; premenopausal (42.1%), perimenopausal (24.4%) and postmenopausal (33.5%). At the time of the survey, 9.8% were receiving hormonal therapy (HT) for the menopause, 1.5% were on psychotropic drugs and 1.2% on alternative treatments for the menopausal. Regarding partner profile, 10.3% had erectile dysfunction, 11.2% had precocious ejaculation and 7.3% had abused alcohol. Mean total MRS score was 9.1 +/- 6.4 (median 9); for the somatic subscale, 4 +/- 2.7; the psychological subscale, 3 +/- 2.8 and the urogenital subscale, 2.1 +/- 2.5. Of the surveyed women, 50.6% presented a total MRS scoring of 9 or more (moderate to severe intensity). The four most frequently found symptoms of those composing the MRS were hot flushes (68.9%), sleeping problems (68.4%), depressive mood (55.2%) and irritability (51.6%). After adjusting for confounding factors, logistic regression analysis determined that female age, menopause and partner precocious ejaculation increased the risk for presenting higher total MRS scores (impaired female QoL) whereas HT use, church assistance and partner faithfulness decreased this risk.
A high rate of middle-aged women in this series presented impaired QoL associated to female age and hormonal status and additionally to partner's health and sexual behavior.
评估女性在绝经过渡期间的生活质量（QoL），并确定与其受损相关的因素（个人因素和伴侣因素）。同时评估绝经症状的发生频率。
在这项横断面研究中，要求40 - 59岁的健康女性填写绝经评定量表（MRS）以及一份评估个人和伴侣人口统计学数据的问卷。
在研究期间，共对409名女性进行了调查。平均年龄为47±5.3岁（中位数为46岁）。平均受教育年限为13.2±4.1年（中位数为14年），其中28.1%的女性受教育年限为12年或更少；绝经前（42.1%）、围绝经期（24.4%）和绝经后（33.5%）。在调查时，9.8%的女性因绝经正在接受激素治疗（HT），1.5%的女性正在服用精神药物，1.2%的女性正在接受绝经替代治疗。关于伴侣情况，10.3%的伴侣存在勃起功能障碍，11.2%的伴侣存在早泄，7.3%的伴侣酗酒。MRS总评分的平均值为9.1±6.4（中位数为9）；躯体亚量表评分为4±2.7；心理亚量表评分为3±2.8；泌尿生殖亚量表评分为2.1±2.5。在接受调查的女性中，50.6%的MRS总评分达到9分或更高（中度至重度）。构成MRS的最常见的四种症状是潮热（68.9%）、睡眠问题（68.4%）、抑郁情绪（55.2%）和易怒（51.6%）。在对混杂因素进行校正后，逻辑回归分析确定女性年龄、绝经状态以及伴侣早泄会增加MRS总评分较高（女性QoL受损）的风险，而使用HT、参加教会活动以及伴侣的忠诚会降低这种风险。
在本研究系列中，相当比例的中年女性存在与女性年龄、激素状态以及伴侣健康和性行为相关的生活质量受损情况。
