Takmaz Tamer, Can Izzet
Ataturk Training and Research Hospital, 2nd Ophthalmology Department, Ankara - Turkey.
Eur J Ophthalmol. 2009 Mar-Apr;19(2):207-13. doi: 10.1177/112067210901900206.
To compare sensitivity and specificity values of glaucoma probability score (GPS) and Moorfields regression analysis (MRA) of Heidelberg retina tomograph (HRT) to discriminate between glaucomatous and healthy eyes.
A total of 160 eyes of 160 individuals (80 glaucoma patients and 80 healthy subjects) were enrolled in this prospective cross-sectional study. Confocal scanning laser ophthalmoscopy was performed with HRT. Performance of GPS and MRA were evaluated by considering borderline (BL) cases as within normal limits (WNL) or as outside normal limits (ONL). For further analysis glaucoma group was divided into two subsets: initial and moderate/severe damage group.
There was no difference between glaucoma patients and normal subjects in terms of gender, disc area, and pachymetry (p>0.05). The GPS was higher, average visual field MD and PSD values were worse, and patients were older in glaucoma group (p=0.001). Sensitivity and specificity values were 72.5% and 93.8% respectively for MRA and 75.0% and 88.8% for GPS when BL cases considered as WNL, and when BL cases considered as ONL these values were 83.8% and 73.8% for MRA and 88.8% and 70.0% for GPS. There was no difference between sensitivity and specificity values of GPS and MRA for either situation (p>0.05). Sensitivity of GPS (76.2%) was higher than of MRA (61.9%) in initial glaucomatous eyes (p=0.317).
Diagnostic performance of GPS was similar to MRA. It was found that GPS might differentiate between glaucomatous and healthy eyes with relatively better sensitivity but worse specificity and represent considerable advantage over MRA in early glaucoma cases.
比较青光眼概率评分（GPS）和海德堡视网膜断层扫描（HRT）的 Moorfields 回归分析（MRA）在鉴别青光眼性眼和健康眼方面的敏感度和特异度值。
本前瞻性横断面研究共纳入 160 名个体的 160 只眼（80 例青光眼患者和 80 名健康受试者）。使用 HRT 进行共焦扫描激光眼底镜检查。通过将临界（BL）病例视为正常范围（WNL）或超出正常范围（ONL）来评估 GPS 和 MRA 的性能。为进一步分析，青光眼组分为两个亚组：初始损伤组和中度/重度损伤组。
青光眼患者与正常受试者在性别、视盘面积和角膜厚度测量方面无差异（p>0.05）。青光眼组的 GPS 更高，平均视野平均缺损（MD）和模式标准差（PSD）值更差，且患者年龄更大（p = ０.００１）。当 BL 病例视为 WNL 时，MRA 的敏感度和特异度值分别为 72.5%和 93.8%，GPS 分别为 75.0%和 88.8%；当 BL 病例视为 ONL 时，MRA 的这些值分别为 83.8%和 73.8%，GPS 的值分别为 88.8%和 70.0%。两种情况下 GPS 和 MRA 的敏感度和特异度值均无差异（p>0.05）。在初始青光眼眼中，GPS 的敏感度（76.2%）高于 MRA（61.9%）（p = 0.317）。
GPS 的诊断性能与 MRA 相似。发现 GPS 可能以相对较高的敏感度但较低的特异度区分青光眼性眼和健康眼，并且在早期青光眼病例中比 MRA 具有相当大的优势。
