10例嗅神经母细胞瘤的临床分析
[Clinical analysis of 10 cases of olfactory neuroblastoma].
作者信息
Wang Hua-Lin, Fan Guo-Kang, Lin Zhi-Hong
机构信息
Department of Otolaryngology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Jan;38(1):103-6. doi: 10.3785/j.issn.1008-9292.2009.01.016.
OBJECTIVE
To review the diagnosis, treatment and prognosis of olfactory neuroblastoma.
METHODS
Clinical data were retrospectively reviewed in 10 cases of olfactory neuroblastoma admitted from 1998 to 2002, including data of transmission electron microscopic (TEM) observation in 4 cases. According to Kadish's classification, 2 cases were in stage A, 4 in stage B and 4 in stage C. Three patients were treated with surgery alone, 7 with combined surgery and radiation.
RESULT
Among 10 cases, the overall 5-year survival rate was 60 %(6/10); 3 patients died from local recurrence, 1 lost follow-up. TEM demonstrated granules in the cytoplasm of 3 patients.
CONCLUSION
The combined surgery and radiation can achieve excellent local control. Transmission electron microscope is important for its diagnosis.
目的
回顾嗅神经母细胞瘤的诊断、治疗及预后情况。
方法
回顾性分析1998年至2002年收治的10例嗅神经母细胞瘤患者的临床资料，其中4例行透射电镜（TEM）观察。根据卡迪什分类，A期2例，B期4例，C期4例。3例仅接受手术治疗，7例接受手术联合放疗。
结果
10例患者中，总体5年生存率为60%（6/10）；3例死于局部复发，1例失访。透射电镜显示3例患者细胞质中有颗粒。
结论
手术联合放疗可实现良好的局部控制。透射电子显微镜对其诊断很重要。
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