Gao Wei, Wang Yinfeng, Wang Yalin, Guo Tao, Li Xianguang, Yin Fei, Pan Chunchen, Sun Jingwu
Department of Otolaryngology Head and Neck Surgery，First Affiliated Hospital of Chinese Academy of Medical Sciences，Hefei，230001，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 Feb;34(2):128-130. doi: 10.13201/j.issn.1001-1781.2020.02.007.
The aim of this study is to evaluate the efficacy of endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma. Forty-three patients with olfactory neuroblastoma undergoing surgery combined with radiotherapy were retrospectively analyzed. The patients were divided into endoscopic surgery and conventional surgery. All patients received postoperative radiotherapy at a dose of 60-70 Gy, the 5-year survival rate and local recurrence time of the two groups were compared, and the therapeutic effects of endoscopic surgery and traditional surgery were compared. Through survival analysis, the 5-year overall survival rates of the traditional surgery group and the endoscopic surgery group were 50% and 58% （=0.560）, the local recurrence rates were 44% and 48% （=0.288）, and the mean recurrence time was 5.6 months and 12.5 months （=0.032）. There was no difference between endoscopic surgery and conventional surgery combined with radiotherapy in the treatment of Neuroblastoma, and the time of local recurrence was significantly prolonged. In early Neuroblastoma, endoscopic sinus surgery may be superior to open surgery in terms of efficacy and patient survival.
本研究旨在评估内镜手术以及传统手术联合放疗治疗神经母细胞瘤的疗效。对43例行手术联合放疗的嗅神经母细胞瘤患者进行回顾性分析。将患者分为内镜手术组和传统手术组。所有患者术后均接受60 - 70 Gy剂量的放疗，比较两组的5年生存率和局部复发时间，并对比内镜手术和传统手术的治疗效果。通过生存分析，传统手术组和内镜手术组的5年总生存率分别为50%和58%（P = 0.560），局部复发率分别为44%和48%（P = 0.288），平均复发时间分别为5.6个月和12.5个月（P = 0.032）。内镜手术与传统手术联合放疗治疗神经母细胞瘤无差异，但局部复发时间显著延长。在早期神经母细胞瘤中，内镜鼻窦手术在疗效和患者生存方面可能优于开放手术。
