Tiul'kova T E, Chugaev Iu P, Kashuba E A, Kulikova I B, Beloborodova N G, Andreeva L V, Kozlova A V, Kozlov N V, Khmeleva E F, Molokova O M
Probl Tuberk Bolezn Legk. 2009(1):51-5.
In modern society, there is a rise in the incidence of tuberculosis in all age groups, including children and adolescents. In old age group, a specific inflammation is detectable from Mantoux test results only in every four children. Tuberculous infection is diagnosed in half of cases when they turn to physicians for complains. Disseminated and complicated forms of tuberculosis are more frequently identified in these situations. The immune system has a particular emphasis on the course and outcome of the disease. The authors have established that caseous masses actively form, followed by the stimulation of the adequate cell pathway promoting the limitation of specific inflammation in old-age group children with primary tuberculosis. In secondary forms of tuberculous infection, there is an increase in the level of monocytes where the persistence and multiplication of the causative microorganism, as well as the activation of the humoral pathway inadequate for tuberculous infection are likely to occur, i.e. the infectious agent may be inhibited until activation of the Th-2 pathway of an immune response takes place.
在现代社会，包括儿童和青少年在内的所有年龄组中结核病的发病率都在上升。在老年组中，每四个儿童中只有一个从结核菌素试验结果中可检测到特定炎症。当因出现症状而就医时，半数病例被诊断为结核感染。在这些情况下，更常发现播散性和复杂性结核病形式。免疫系统对疾病的病程和结果有特别重要的影响。作者已经证实，在老年原发性结核患儿中，干酪样肿块会积极形成，随后刺激适当的细胞途径，促进特定炎症的局限化。在继发性结核感染形式中，单核细胞水平会升高，致病微生物可能在其中持续存在并繁殖，同时可能发生对结核感染不充分的体液途径激活，即病原体可能被抑制，直到免疫反应的Th-2途径被激活。
