抗癌天然产物补骨脂定的全合成。
Total synthesis of psoralidin, an anticancer natural product.
作者信息
Pahari Pallab, Rohr Jürgen
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536-0082, USA.
出版信息
J Org Chem. 2009 Apr 3;74(7):2750-4. doi: 10.1021/jo8025884.
Abstract
A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.
摘要
乙酸苯酯与酰氯在碱催化下缩合，随后进行分子内环化和微波辅助交叉复分解反应，以高度汇聚和区域选择性的方式首次全合成了补骨脂定，一种具有广泛生物活性的天然产物。
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