来自中国天然药物的生物活性成分。XX。补骨脂种子中RBL - 2H3细胞抗原诱导脱颗粒的抑制剂。
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia.
作者信息
Matsuda Hisashi, Sugimoto Sachiko, Morikawa Toshio, Matsuhira Koudai, Mizuguchi Eri, Nakamura Seikou, Yoshikawa Masayuki
机构信息
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2007 Jan;55(1):106-10. doi: 10.1248/cpb.55.106.
The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of beta-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells. Sixteen constituents were isolated from the ethyl acetate-soluble fraction and several constituents, Delta(1),3-hydroxybakuchiol (IC(50) = 49 microM), Delta(3),2-hydroxybakuchiol (69 microM, bavachin (58 microM), and psoralidin (ca. 100 microM), showed inhibitory activities against the antigen-induced degranulation.
补骨脂种子甲醇提取物的乙酸乙酯可溶部分被发现能抑制β-己糖胺酶的释放，β-己糖胺酶是RBL-2H3细胞中抗原-IgE诱导脱颗粒的标志物。从乙酸乙酯可溶部分分离出16种成分，其中几种成分，Δ(1),3-羟基补骨脂酚（IC50 = 49微摩尔）、Δ(3),2-羟基补骨脂酚（69微摩尔）、补骨脂素（58微摩尔）和补骨脂定（约100微摩尔），对抗原诱导的脱颗粒表现出抑制活性。
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