通过对韩国个体的基因组DNA进行测序鉴定新型HLA-G*010112等位基因。

Identification of the novel HLA-G*010112 allele by sequencing genomic DNA of Korean individuals.

作者信息

Kim J-G, Yun H-S, Lee J-K, Kwack K

机构信息

School of Biological Science and Technology, Pochon CHA University, Sungnam, Korea.

出版信息

Tissue Antigens. 2009 Mar;73(3):281-3. doi: 10.1111/j.1399-0039.2008.01209.x.

DOI:10.1111/j.1399-0039.2008.01209.x

PMID:19254264

Abstract

Human leukocyte antigen (HLA)-G is an immune modulator that inhibits the functions of cytotoxic T lymphocytes and natural killer cells. Immune modulation of HLA-G plays an important role in the prevention of fetal rejection. We found a novel substitution at nucleotide position 195 (G-T), codon 41 (Ala), in exon 2 of HLA-G. This substitution does not change the amino acid (GCG-->GCT).

摘要

人类白细胞抗原（HLA）-G是一种免疫调节剂，可抑制细胞毒性T淋巴细胞和自然杀伤细胞的功能。HLA-G的免疫调节在防止胎儿排斥反应中起重要作用。我们在HLA-G外显子2的核苷酸位置195（G-T）、密码子41（丙氨酸）处发现了一个新的替换。这种替换不会改变氨基酸（GCG→GCT）。