Murray John M, McDonald Ann M, Law Matthew G
School of Mathematics and Statistics, University of New South Wales, Sydney, NSW 2052, Australia.
Sex Health. 2009 Mar;6(1):83-6. doi: 10.1071/sh08063.
Antiretroviral therapy has increased survival for individuals living with HIV and has led to an ageing of this population in developed countries. To date the rate of ageing has been unquantified, giving rise to uncertainty in the treatment emphasis and burden in this population.
A mathematical model was used in conjunction with HIV/AIDS data from the Australian National HIV/AIDS Registry to estimate numbers and ages of Australian men who have sex with men (MSM) living with HIV infection from 1980 to 2005.
The average age of HIV-infected Australian MSM is estimated to exceed 44 years of age by the year 2010 and has increased by 1 year of age for each two calendar years since the mid-1980s. HIV-infected MSM over 60 years of age have been increasing in number by 12% per year since 1995. A consequence of successful therapy with subsequent ageing of those infected has meant that from 2001 estimated deaths from other causes exceed AIDS deaths in Australia.
In summary, our analyses indicate an increasing and rapidly ageing population living with HIV in Australia. This will inevitably lead to more serious non-AIDS conditions in ageing patients living with HIV, and to increased treatment complexity.
抗逆转录病毒疗法提高了艾滋病毒感染者的存活率,并导致发达国家这一人群的老龄化。迄今为止,老龄化速度尚未得到量化,这使得该人群的治疗重点和负担存在不确定性。
使用一个数学模型,并结合澳大利亚国家艾滋病毒/艾滋病登记处的艾滋病毒/艾滋病数据,来估计1980年至2005年期间感染艾滋病毒的澳大利亚男男性行为者(MSM)的人数和年龄。
据估计,到2010年,感染艾滋病毒的澳大利亚男男性行为者的平均年龄将超过44岁,自20世纪80年代中期以来,每两个日历年平均年龄就增加1岁。自1995年以来,60岁以上感染艾滋病毒的男男性行为者人数每年以12%的速度增长。成功治疗以及感染者随后的老龄化导致,自2001年以来,澳大利亚因其他原因导致的估计死亡人数超过了艾滋病死亡人数。
总之,我们的分析表明,澳大利亚感染艾滋病毒的人群在不断增加且老龄化迅速。这将不可避免地导致感染艾滋病毒的老年患者出现更严重的非艾滋病病症,并增加治疗的复杂性。