Pedrazzini G B, Saglini V, Pedrinis E, Mombelli G, Domenighetti G
Unità di Cure intense, Ospedale regionale La Carità, Locarno.
Schweiz Med Wochenschr. 1991 Sep 7;121(36):1293-7.
Paraquat is a potent herbicide, very toxic in the concentrated liquid form as supplied to farmers. Suicidal poisoning represents a serious emergency with a known high mortality rate. Suicidal poisoning following the parenteral route has been rarely reported. A 16-year-old girl was admitted to our emergency unit after subcutaneous injection of gramoxone 20% (about 400 mg of paraquat). Despite immediate surgical excision and revision, and subsequent antioxidant treatment with N-acetylcysteine (400 mg/kg/day during 48 hours), she died 17 days later from refractory hypoxemia following pulmonary fibrosis. From this observation and from the literature, it appears that an effective treatment does not depend on changes in the toxicokinetics of the herbicide (hemoperfusion, antidotes, drugs).
百草枯是一种强效除草剂，以供应给农民的浓缩液形式存在时毒性很强。自杀性中毒是一种严重的紧急情况，已知死亡率很高。经胃肠外途径的自杀性中毒鲜有报道。一名16岁女孩在皮下注射20%的克芜踪（约400毫克百草枯）后被送入我们的急诊室。尽管立即进行了手术切除和清创，随后用N-乙酰半胱氨酸进行了抗氧化治疗（48小时内每天400毫克/千克），但她在17天后死于肺纤维化后的难治性低氧血症。从这一观察结果和文献来看，似乎有效的治疗并不取决于除草剂毒代动力学的改变（血液灌流、解毒剂、药物）。
