Hughes J T
Department of Neuropathology, Radcliffe Infirmary, Oxford, England.
Neurotoxicology. 1988 Summer;9(2):243-8.
A 20-year-old man committed suicide by drinking 50-100 ml of a 20% solution of Paraquat (Gramoxone). He died 24 days later from progressive pulmonary fibrosis (Paraquat lung) despite intensive therapy to combat the toxicity of the poison to lung, kidney, and liver. At necropsy, brain damage was found in the form of moderate neuronal depletion, probably secondary to anoxia, and damage to the central white matter and particularly the brain around the lateral and third ventricles. Examination of the brain by electron microscopy showed oedema and destruction of myelin with abundant myelin breakdown products, and astrocytic fibrous gliosis.
一名20岁男子饮用了50 - 100毫升20%的百草枯（克无踪）溶液自杀。尽管进行了强化治疗以对抗该毒药对肺、肾和肝脏的毒性，但他在24天后死于进行性肺纤维化（百草枯肺）。尸检时，发现脑部有中度神经元缺失形式的损伤，可能继发于缺氧，以及中枢白质尤其是侧脑室和第三脑室周围脑组织的损伤。电子显微镜检查脑部显示有水肿、髓鞘破坏并有大量髓鞘分解产物，以及星形细胞纤维性胶质增生。
