Inoue Masayuki, Lee Nayoung, Tsumuraya Takeshi, Fujii Ikuo, Hirama Masahiro
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Toxicon. 2009 Jun;53(7-8):802-5. doi: 10.1016/j.toxicon.2009.02.017. Epub 2009 Feb 28.
Ciguatera is a global food poisoning caused by the consumption of fish that have accumulated sodium channel activator toxins, ciguatoxins. At present, most diagnosed cases of ciguatera are treated with symptomatic and supportive remedies, and no specific therapy has been devised. Here we report that ciguatoxin CTX3C can be effectively neutralized in vitro and in vivo by simultaneous use of two anti-ciguatoxin monoclonal antibodies, providing the first rational approach toward directly preventing and treating ciguatera.
雪卡毒素中毒是一种因食用积聚了钠通道激活毒素（雪卡毒素）的鱼类而导致的全球性食物中毒。目前，大多数已确诊的雪卡毒素中毒病例采用对症和支持性治疗，尚未设计出特效疗法。在此，我们报告，同时使用两种抗雪卡毒素单克隆抗体，可在体外和体内有效中和雪卡毒素CTX3C，这为直接预防和治疗雪卡毒素中毒提供了首个合理方法。
