Pang Lisa Y, Argyle David J
University of Edinburgh, Midlothian EH25 9RG, Scotland, UK.
Biochim Biophys Acta. 2009 Apr;1792(4):380-91. doi: 10.1016/j.bbadis.2009.02.010. Epub 2009 Feb 28.
The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and tumour genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems.
最近描述的癌症干细胞理论为确定治疗干预靶点带来了许多新的挑战和机遇。然而，大多数癌症相关治疗研究依赖于人类癌症的啮齿动物模型，而这些模型很少能转化为人类患者的临床成功。犬、猫和人类的自然发生癌症具有共同的生物学特征，包括分子靶点、端粒酶生物学和肿瘤遗传学。研究患癌宠物群体中的癌症干细胞生物学和端粒/端粒酶动态变化，可能为更深入了解自然环境中的癌症生物学以及评估针对这些系统的新型疗法的开发提供机会。
