Wang Ping, Li Shiyou, Ownby Stacy, Zhang Zhizhen, Yuan Wei, Zhang Wanli, Scott Beasley R
National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962, USA.
Phytochemistry. 2009 Feb;70(3):430-6. doi: 10.1016/j.phytochem.2009.01.017. Epub 2009 Feb 28.
Phytoecdysteroid glycosides (1-5) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (7-9), four flavonoids (10-13), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 6-14 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC(50) of 130 microM in conjunction with low intercalation ability.
