• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2',3'-二脱氧-和2',3'-二脱氧-2',3'-二脱氢-腺苷及肌苷的噻吩并[3,4-d]嘧啶C-核苷类似物的合成与抗病毒评价

Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.

作者信息

Hamann Marie, Pierra Claire, Sommadossi Jean-Pierre, Musiu Chiara, Vargiu Luana, Liuzzi Michel, Storer Richard, Gosselin Gilles

机构信息

Idenix Pharmaceuticals, Medicinal Chemistry Laboratories IDENIX Sarl, Cap Gamma, 1682 rue de la Valsière, 34189 Montpellier Cedex 4, France.

出版信息

Bioorg Med Chem. 2009 Mar 15;17(6):2321-6. doi: 10.1016/j.bmc.2009.02.011. Epub 2009 Feb 14.

DOI:10.1016/j.bmc.2009.02.011
PMID:19254848
Abstract

Several thieno[3,4-d]pyrimidine derivatives, including four hitherto unknown 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in cell culture experiments against human immunodeficiency virus, none of the tested compounds exhibited any significant antiviral effect, while two of them showed some cytotoxicity.

摘要

已经合成了几种噻吩并[3,4-d]嘧啶衍生物，包括四种迄今未知的腺苷和肌苷的2'，3'-二脱氧以及2'，3'-二脱氧-2'，3'-二脱氢-C-核苷类似物。在细胞培养实验中对这些化合物进行抗人免疫缺陷病毒评估时，所测试的化合物均未表现出任何显著的抗病毒作用，而其中两种显示出一定的细胞毒性。

相似文献

1
Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.2',3'-二脱氧-和2',3'-二脱氧-2',3'-二脱氢-腺苷及肌苷的噻吩并[3,4-d]嘧啶C-核苷类似物的合成与抗病毒评价
Bioorg Med Chem. 2009 Mar 15;17(6):2321-6. doi: 10.1016/j.bmc.2009.02.011. Epub 2009 Feb 14.
2
Synthesis of substituted thieno[2,3-d]pyrimidine-2,4-dithiones and their S-glycoside analogues as potential antiviral and antibacterial agents.取代噻吩并[2,3-d]嘧啶-2,4-二硫酮及其 S-糖基类似物的合成作为潜在的抗病毒和抗菌剂。
Eur J Med Chem. 2010 Sep;45(9):4026-34. doi: 10.1016/j.ejmech.2010.05.060. Epub 2010 Jun 2.
3
Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.L-碳环2'，3'-二脱氢-2'，3'-二脱氧核苷及2'，3'-二脱氧核苷的不对称合成与抗病毒活性
J Med Chem. 1999 Aug 26;42(17):3390-9. doi: 10.1021/jm9901327.
4
Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.5-炔基-和6-烷基呋喃并及吡咯并[2,3-d]嘧啶核糖核苷的2'-C-甲基类似物的合成与抗病毒评价
Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):713-23. doi: 10.1080/15257770903128870.
5
Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.新型C-5取代嘧啶和呋喃并[2,3-d]嘧啶4',5'-二脱氢-L-抗坏血酸衍生物的合成、抗病毒及细胞生长抑制活性评价
J Med Chem. 2007 Aug 23;50(17):4105-12. doi: 10.1021/jm070324z. Epub 2007 Aug 2.
6
Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity.合成及筛选一些新型噻吩并[2,3-b]噻吩并嘧啶衍生物以对抗抗禽流感病毒（H5N1）活性。
Eur J Med Chem. 2010 Nov;45(11):5251-7. doi: 10.1016/j.ejmech.2010.08.044. Epub 2010 Aug 24.
7
Synthesis and antiviral screening of some thieno[2,3-d]pyrimidine nucleosides.某些噻吩并[2,3-d]嘧啶核苷的合成与抗病毒筛选
Nucleosides Nucleotides Nucleic Acids. 2006;25(1):17-28. doi: 10.1080/15257770500377730.
8
Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.具有抗HIV和HBV强效活性的碳环2',3'-二脱氧-2',3'-二脱氢-7-脱氮腺苷的磷酰胺酯前药。
Nucleosides Nucleotides Nucleic Acids. 2004;23(12):1929-37. doi: 10.1081/NCN-200040678.
9
Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.新型C-6氟代无环侧链嘧啶衍生物：合成、（1）H和（13）C NMR构象研究以及抗病毒和细胞生长抑制活性评估
J Med Chem. 2007 Jun 28;50(13):3037-45. doi: 10.1021/jm0614329. Epub 2007 Jun 1.
10
Synthesis of pyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine derivatives for antiviral evaluation.用于抗病毒评估的吡唑并[4',3':5,6]吡喃并[2,3-d]嘧啶衍生物的合成
Arch Pharm (Weinheim). 2007 May;340(5):236-43. doi: 10.1002/ardp.200700005.

引用本文的文献

1
Drug Discovery and Exploration of Heterocycles for the Development of Anti-HIV Agents.用于抗HIV药物开发的杂环类药物发现与探索
Infect Disord Drug Targets. 2025;25(3):e18715265290911. doi: 10.2174/0118715265290911240611072422.