4-氧代-4H-喹嗪-3-羧酸衍生物的设计、合成及抗HIV整合酶活性评价
Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivatives.
作者信息
Xu Yi-Sheng, Zeng Cheng-Chu, Jiao Zi-Guo, Hu Li-Ming, Zhong Ru-gang
机构信息
Beijing University of Technology, P. R. China.
出版信息
Molecules. 2009 Feb 19;14(2):868-83. doi: 10.3390/molecules14020868.
Abstract
4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
摘要
已设计并合成了带有磺酰胺基、羧酰胺基、苯并咪唑和苯并噻唑取代基的4-氧代-4H-喹嗪-3-羧酸衍生物。这些新化合物的结构通过(1)H-NMR、(13)C-NMR、IR和ESI（或HRMS）光谱得到证实。对化合物进行了潜在的HIV整合酶抑制活性筛选。
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