Department of Medicine, Center for Esophageal Disease, New York University School of Medicine, New York, NY 10016, USA.
Dig Dis Sci. 2010 Feb;55(2):346-50. doi: 10.1007/s10620-009-0752-1. Epub 2009 Mar 3.
The aim of this study was to characterize the reflux events in patients with laryngeal symptoms unresponsive to proton pump inhibitor (PPI) therapy.
Gastroesophageal reflux disease (GERD) is commonly implicated as the cause of laryngeal symptoms.
We retrospectively reviewed the pH/impedance records of 21 patients evaluated for persistent throat symptoms despite PPI therapy. They were compared to 30 others with typical reflux symptoms despite medication.
Five of 21 (24%) patients in the "throat group" had normal reflux values, 13 (62%) continued to have abnormal acid reflux, and three (14%) had abnormal nonacid reflux but normal acid reflux while on medication. These results did not differ from those with typical symptoms unresponsive to medication.
In patients with chronic laryngeal symptoms despite PPI therapy, a substantial minority have no reflux at all, but the majority have abnormal amounts of acid reflux despite their taking PPI medication.
本研究旨在描述经质子泵抑制剂（PPI）治疗后仍有喉部症状的患者的反流事件。
胃食管反流病（GERD）通常被认为是喉部症状的原因。
我们回顾性分析了 21 例经 PPI 治疗后持续性咽喉症状患者的 pH/阻抗记录，并与 30 例有典型反流症状但经药物治疗的患者进行了比较。
在“咽喉组”的 21 例患者中，有 5 例（24%）的反流值正常，13 例（62%）持续存在异常酸反流，3 例（14%）存在异常非酸反流，但在药物治疗时酸反流正常。这些结果与对药物无反应的典型症状患者没有差异。
在经 PPI 治疗后仍有慢性喉部症状的患者中，相当一部分患者根本没有反流，但大多数患者尽管服用了 PPI 药物，仍有异常量的酸反流。
