Wang Kevin C, Zane Lee T
Department of Dermatology, University of California at San Francisco School of Medicine, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA.
Adv Dermatol. 2008;24:197-209. doi: 10.1016/j.yadr.2008.09.002.
Understanding of acne vulgaris has taken major steps forward over the past few years. The renewed interest in the effect of dietary interventions on acne, the elucidation of the involvement of TLR and MMPs in acne pathogenesis, and a more detailed functional understanding of various treatment modalities at the molecular level are all promising indications that advances in therapeutics are sure to follow. Health utilities will serve not only as powerful outcome measures of treatment effects but also as clinical decision-making aids in everyday practice. It is hoped that future advances will further uncover additional molecular and cellular details of pathophysiology, leading to rational targeted design of medications, and advance clinical management through improved understanding of the psychosocial impact of acne on patients.
在过去几年里，对寻常痤疮的认识取得了重大进展。人们对饮食干预对痤疮的影响重新产生兴趣，对Toll样受体（TLR）和基质金属蛋白酶（MMPs）在痤疮发病机制中的作用有了更清晰的认识，并且在分子水平上对各种治疗方式有了更详细的功能理解，这些都是治疗方法必将取得进展的有力迹象。健康效用不仅将作为治疗效果的有力指标，还将在日常实践中作为临床决策的辅助工具。希望未来的进展将进一步揭示病理生理学的更多分子和细胞细节，从而实现药物的合理靶向设计，并通过更好地理解痤疮对患者的心理社会影响来推进临床管理。
