Nguyen Q H, Kim Y A, Schwartz R A
UCLA School of Medicine.
Am Fam Physician. 1994 Jul;50(1):89-96, 99-100.
Acne vulgaris can affect both adolescents and adults. The pathogenesis of acne is multifactorial and involves overproduction of sebum, an abnormal follicular keratinization process, proliferation of Propionibacterium acnes, and hormonal and immunologic factors. Clinical manifestations of acne range from noninflammatory comedones to inflammatory papules, pustules and cysts. Current therapy allows the physician to select a variety of topical and/or systemic antibiotics, retinoids, and hormone agents aimed at specific pathogenic factors. Most treatment regimens require several weeks of consistent use to be effective. Sound patient education, a strong therapeutic alliance and modification of lifestyle factors are powerful adjuncts to medical management.
寻常痤疮可影响青少年和成年人。痤疮的发病机制是多因素的，包括皮脂过度分泌、毛囊角化异常、痤疮丙酸杆菌增殖以及激素和免疫因素。痤疮的临床表现从非炎性粉刺到炎性丘疹、脓疱和囊肿不等。目前的治疗方法使医生能够选择多种针对特定致病因素的外用和/或全身性抗生素、维甲酸和激素药物。大多数治疗方案需要持续使用数周才有效。良好的患者教育、牢固的治疗联盟以及生活方式因素的改变是医疗管理的有力辅助手段。
