谷胱甘肽S-转移酶M1（存在/缺失）和谷胱甘肽S-转移酶P1（Ile105Val）基因多态性在印度南部人群急性淋巴细胞白血病易感性中的作用。
Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population.
作者信息
Suneetha K J, Nancy K Nirmala, Rajalekshmy K R, Sagar T G, Rajkumar T
机构信息
Dept of Molecular Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.
出版信息
Asian Pac J Cancer Prev. 2008 Oct-Dec;9(4):733-6.
Acute lymphoblastic leukaemia (ALL) is the most common pediatric malignancy worldwide. The origin of this disease may be explained by a combination of genetic and environmental factors. Glutathione-s-transferases are a multi-gene family of enzymes involved in the detoxification of a wide variety of environmental carcinogens. A total of 92 immunophenotyped cases (below 25 years of age) and 150 cord blood controls were here analysed by PCR for GSTM1(Present/Null) and RQ-PCR allelic discrimination assay for GSTP1(Ile105Val). We found a significant increased risk for ALL with the GSTM1 null genotype (OR: 1.96, 95%CI=1.08-3.57), but no significant risk was found with the GSTP1 (Ile/Val) genotype (OR: 1.32, 95%CI = 0.74-2.37) and the GSTP1 Val/Val genotype (OR: 1.41, 95%CI=0.5-3.96) alone. Combined analysis of GSTM1 and GSTP1 showed significant higher risk associated with the GSTM1 (null/null) and GSTP1 [(Ile/Val)/ (Val/Val)] genotype (OR=2.78: 95%CI=1.16-6.69).
急性淋巴细胞白血病（ALL）是全球最常见的儿童恶性肿瘤。这种疾病的起源可以用遗传和环境因素的综合作用来解释。谷胱甘肽 - S - 转移酶是一个多基因家族的酶，参与多种环境致癌物的解毒过程。本研究通过聚合酶链反应（PCR）分析了92例免疫表型病例（年龄在25岁以下）和150例脐血对照样本中的GSTM1（存在/缺失）情况，并通过实时定量聚合酶链反应（RQ - PCR）等位基因鉴别分析检测了GSTP1（Ile105Val）。我们发现GSTM1基因缺失型与ALL发病风险显著增加相关（比值比：1.96，95%置信区间=1.08 - 3.57），但单独的GSTP1（Ile/Val）基因型（比值比：1.32，95%置信区间 = 0.74 - 2.37）和GSTP1 Val/Val基因型（比值比：1.41，95%置信区间=0.5 - 3.96）未发现显著风险。GSTM1和GSTP1的联合分析显示，GSTM1（缺失/缺失）和GSTP1 [（Ile/Val）/（Val/Val）]基因型与显著更高的风险相关（比值比=2.78：95%置信区间=1.16 - 6.69）。
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