Morant Pierre-Emmanuel, Thommen Quentin, Lemaire François, Vandermoëre Constant, Parent Benjamin, Lefranc Marc
Université des Sciences et Technologies de Lille, PhLAM, F-59655 Villeneuve d'Ascq, France.
Phys Rev Lett. 2009 Feb 13;102(6):068104. doi: 10.1103/PhysRevLett.102.068104.
We revisit the dynamics of a gene repressed by its own protein in the case where the transcription rate does not adapt instantaneously to protein concentration but is a dynamical variable. We derive analytical criteria for the appearance of sustained oscillations and find that they require degradation mechanisms much less nonlinear than for infinitely fast regulation. Deterministic predictions are confirmed by stochastic simulations of this minimal genetic oscillator.
我们重新审视了一种由其自身蛋白质抑制的基因的动力学情况，即转录速率并非瞬间适应蛋白质浓度，而是一个动态变量。我们推导出了持续振荡出现的分析标准，并发现与无限快速调节相比，它们所需的降解机制的非线性程度要低得多。这种最小遗传振荡器的随机模拟证实了确定性预测。
