Santos Ina S, Boccio Jose, Davidsson Lena, Hernandez-Triana Manuel, Huanca-Sardinas Elizabeth, Janjetic Mariana, Moya-Camarena Silvia Y, Paez-Valery Maria C, Ruiz-Alvarez Vladimir, Valencia Mauro E, Valle Neiva C J, Vargas-Pinto Greta, Solano Liseti, Thomas Julian
Postgraduate Course Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro 1160, Pelotas, RS, Brazil.
Public Health Nutr. 2009 Oct;12(10):1862-70. doi: 10.1017/S1368980009004789. Epub 2009 Mar 4.
To investigate the association between Helicobacter pylori infection and anaemia.
Six cross-sectional studies. H. pylori infection was assessed by the [13C]urea breath test using MS or IR analysis. Hb was measured for all countries. Ferritin and transferrin receptors were measured for Argentina, Bolivia, Mexico, and Venezuela.
Health services in Argentina, Brazil and Mexico or public schools in Bolivia, Cuba and Venezuela.
In Argentina, 307 children aged 4-17 years referred to a gastroenterology unit; in Bolivia, 424 randomly selected schoolchildren aged 5-8 years; in Brazil, 1007 adults (157 men, 850 women) aged 18-45 years attending thirty-one primary health-care units; in Cuba, 996 randomly selected schoolchildren aged 6-14 years; in Mexico, seventy-one pregnant women in their first trimester attending public health clinics; in Venezuela, 418 children aged 4-13 years attending public schools.
The lowest prevalence of H. pylori found was among children in Argentina (25.1%) and the highest in Bolivia (74.0%). In Bolivia, Cuba and Venezuela children showed similar prevalence of H. pylori infection as in Brazilian and Mexican adults (range 47.5% to 81.8%). Overall anaemia prevalence was 11.3% in Argentina, 15.4% in Bolivia, 20.6% in Brazil, 10.5% in Cuba and 8.9% in Venezuela. Adjusted analyses allowing for confounding variables showed no association between H. pylori colonization and anaemia in any study. Hb, ferritin and transferrin receptor levels were also not associated with H. pylori infection in any country.
The present study showed no evidence to support the hypothesis that H. pylori contributes to anaemia in children, adolescents, adults or pregnant women in six Latin American countries.
探讨幽门螺杆菌感染与贫血之间的关联。
六项横断面研究。采用质谱（MS）或红外（IR）分析的[¹³C]尿素呼气试验评估幽门螺杆菌感染情况。对所有国家的血红蛋白（Hb）进行了测量。对阿根廷、玻利维亚、墨西哥和委内瑞拉的铁蛋白和转铁蛋白受体进行了测量。
阿根廷、巴西和墨西哥的卫生服务机构，或玻利维亚、古巴和委内瑞拉的公立学校。
在阿根廷，307名4至17岁转诊至胃肠病科的儿童；在玻利维亚，424名随机选取的5至8岁学童；在巴西，1007名年龄在18至45岁之间、前往31个初级卫生保健机构就诊的成年人（157名男性，850名女性）；在古巴，996名随机选取的6至14岁学童；在墨西哥，71名在公立卫生诊所就诊的孕早期孕妇；在委内瑞拉，418名在公立学校就读的4至13岁儿童。
幽门螺杆菌感染率最低的是阿根廷的儿童（25.1%），最高的是玻利维亚（74.0%）。在玻利维亚、古巴和委内瑞拉，儿童幽门螺杆菌感染率与巴西和墨西哥成年人相似（范围为47.5%至81.8%）。总体贫血患病率在阿根廷为11.3%，在玻利维亚为15.4%，在巴西为20.6%，在古巴为10.5%，在委内瑞拉为8.9%。考虑混杂变量的校正分析显示，在任何研究中幽门螺杆菌定植与贫血之间均无关联。在任何国家，血红蛋白、铁蛋白和转铁蛋白受体水平也与幽门螺杆菌感染无关。
本研究没有证据支持幽门螺杆菌导致六个拉丁美洲国家儿童、青少年、成年人或孕妇贫血这一假设。
