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沙特阿拉伯阿西尔地区的感染相关性贫血

() Infection-Associated Anemia in the Asir Region, Saudi Arabia.

作者信息

Al Mutawa Omar A, Izhari Mohammad Asrar, Alharbi Raed A, Sindi Abdulmajeed Abdulghani A, Alqarni Abdullah M, Alotaibi Foton E, Gosady Ahmed R A, Dardari Daifallah M M, Almutairi Abdulrahman M, Alshehri Mohammed, Athathi Ahmed I E

机构信息

Medical Laboratory Department Southern Region Armed Forces Hospital, Khamis Mushait 62413, Saudi Arabia.

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha 65528, Saudi Arabia.

出版信息

Diagnostics (Basel). 2023 Jul 18;13(14):2404. doi: 10.3390/diagnostics13142404.

Abstract

(ubiquitous) and anemia together represent one of the growing health concerns globally. Gastroduodenal sequelae of infection are distinguished; however, for the infection and its implication in the development of anemia, iron has a significant health impact. We aimed to evaluate infection-associated anemia by employing a logistic regression analysis model. A retrospective (case-control) study design-based assessment of the associated-anemia. The study area was geo-referenced by QGIS/QuickMapServies. Descriptive and inferential statistical analyses were accomplished using the R-base-R-studio (v-4.0.2)-tidyverse. A -value < 0.05 was the statistical significance cut-off value. A ggplot2 package was used for data representation and visualization. Mean ± SD age, Hb, MCV, ferritin, and RBC for overall study participants were measured to be 44.0 ± 13.58, 13.84 ± 2.49, 83.02 ± 8.31, 59.42 ± 68.37, and 5.14 ± 0.75, respectively. Decreased levels of Hb (infected vs. uninfected: 13.26 ± 2.92 vs. 14.42 ± 1.75, < 0.001) ferritin (infected vs. uninfected: 48.11 ± 63.75 vs. 71.17 ± 71.14, < 0.001), and MCV (infected vs. uninfected: 81.29 ± 9.13 vs. and 84.82 ± 6.93, < 0.05) were measured to be associated with infection when compared with uninfected control group. Moreover, the magnitude (prevalence) of anemia (infected vs. uninfected: 78% vs. 21%, < 0.001), iron deficiency anemia (IDA) (infected vs. uninfected: 63.3% vs. 36.6%, < 0.001), and microcytic anemia (infected vs. uninfected: 71.6% vs. 46.1%, < 0.001) were significantly different among the -infected participants. The higher likelihood of developing anemia (AOR; 4.98, 95% CI; 3.089-8.308, < 0.001), IDA (AOR; 3.061, 95% CI; 2.135-4.416, < 0.001), and microcytic anemia (AOR; 3.289, 95% CI; 2.213-4.949, < 0.001) by 398%, 206.1%, and 229%, respectively, was associated with -infected. We recommend the regular monitoring of hematological parameters and eradication of infection to minimize the extra-gastric health consequences of infection.

摘要

(普遍存在的)[某种感染]与贫血共同构成了全球日益严重的健康问题之一。感染的胃十二指肠后遗症是有区别的;然而,对于[这种感染]及其在贫血发展中的影响,铁具有重大的健康影响。我们旨在通过使用逻辑回归分析模型来评估[感染]相关的贫血。基于回顾性(病例对照)研究设计对[感染]相关贫血进行评估。研究区域通过QGIS/QuickMapServies进行地理定位。使用R-base-R-studio(v-4.0.2)-tidyverse完成描述性和推断性统计分析。P值<0.05为统计显著性临界值。使用ggplot2包进行数据表示和可视化。总体研究参与者的平均±标准差年龄、血红蛋白(Hb)、平均红细胞体积(MCV)、铁蛋白和红细胞(RBC)分别测得为44.0±13.58、13.84±2.49、83.02±8.31、59.42±68.37和5.14±0.75。与未感染对照组相比,感染组的血红蛋白水平降低(感染组与未感染组:13.26±2.92 vs. 14.42±1.75,P<0.001)、铁蛋白水平降低(感染组与未感染组:48.11±63.75 vs. 71.17±71.14,P<0.001)以及平均红细胞体积降低(感染组与未感染组:81.29±9.13 vs. 84.82±6.93,P<0.05),这些均与[这种感染]相关。此外,感染参与者中贫血的发生率(感染组与未感染组:78% vs. 21%,P<0.001)、缺铁性贫血(IDA)(感染组与未感染组:63.3% vs. 36.6%,P<0.001)和小细胞性贫血(感染组与未感染组:71.6% vs. 46.1%,P<0.001)存在显著差异。感染[这种感染]导致患贫血的可能性更高(比值比[AOR];4.98,95%置信区间[CI];3.089 - 8.308,P<0.001)、患缺铁性贫血的可能性更高(AOR;3.061,95% CI;2.135 - 4.4

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c01f/10378611/cbcfaeaf6bb9/diagnostics-13-02404-g001.jpg

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