Mannell A, Hunter S J, Hale M J
Department of Surgery, South African Institute for Medical Research, Johannesburg.
S Afr J Surg. 1991 Sep;29(3):120-2.
Primary malignant melanoma is a very rare tumour of the oesophagus, and although this is the first case reported in a black patient in South Africa, the clinical, radiographic and histopathological features were characteristic of this malignancy. Primary oesophageal melanoma is a highly lethal tumour--fewer than 2% of patients are surviving 5 years after diagnosis. Flow cytometric DNA analysis of the resected specimen in this case revealed two populations of malignant cells, one of which had grossly abnormal DNA. Existence of two clones of malignant melanoma cells supports the observations that this tumour is biologically aggressive, radioresistant and almost always incurable.
原发性恶性黑色素瘤是一种非常罕见的食管肿瘤，尽管这是南非首例报道的黑人患者病例，但该恶性肿瘤的临床、影像学和组织病理学特征均具有典型性。原发性食管黑色素瘤是一种高度致命的肿瘤——确诊后存活5年以上的患者不到2%。该病例切除标本的流式细胞术DNA分析显示有两群恶性细胞，其中一群的DNA严重异常。恶性黑色素瘤细胞两个克隆的存在支持了以下观点：该肿瘤具有生物学侵袭性、对放疗耐药且几乎总是无法治愈。
